Toxicological Impacts of Pharmaceutical Industrial Effluents on Hematology, Biochemical and Histological Indices of Rattus Novergicus
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International Journal of Recent Engineering Science (IJRES) |  |
| © 2024 by IJRES Journal | ||
| Volume-11 Issue-5 |
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| Year of Publication : 2024 | ||
| Authors : Fatukasi B. Adetutu, Fawole O. Olubanjo, Oladapo, O.Omoniyi, Olatunji, J.Tope |
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| DOI : 10.14445/23497157/IJRES-V11I5P103 |
How to Cite?
Fatukasi B. Adetutu, Fawole O. Olubanjo, Oladapo, O.Omoniyi, Olatunji, J.Tope, "Toxicological Impacts of Pharmaceutical Industrial Effluents on Hematology, Biochemical and Histological Indices of Rattus Novergicus," International Journal of Recent Engineering Science, vol. 11, no. 5, pp. 21-32, 2024. Crossref, https://doi.org/10.14445/23497157/IJRES-V11I5P103
Abstract
The most harmful and potentially lethal wastes are heavy metals. In this investigation, the hematology, biochemical and histopathological effects on Rattus novergicus of the compositions of effluent from the pharmaceutical industry were evaluated. The effluent was taken from a pharmaceutical industry at Ilorin, Kwara State. Thirty-six (36) laboratory rats were obtained, and six groups were made up of each of the six rats. The first group was served as the control group. Distilled water was given to them, while groups 2 to 5 had 20, 40, 60, 80 and 100 % v/v of the pharmaceutical effluent as the exclusive water source, respectively. By the fourth week, the rats were sacrificed for hematology and biochemical analysis, and GraphPad Prism version 5.0 was used, while the liver and the kidney were subjected to histopathological examinations, which showed mild portal congestion and mild to moderate periporal cellular infiltration in the liver and focal extension area of tubular degeneration, necrosis around the renal capsule, and moderate interstitial congestion of the kidney due to the concentrations of the effluents. These results demonstrate that the rats were fairly impacted, which may confirm the effect on aquatic and terrestrial life forms that depend on the river for home and agricultural purposes.
Keywords
Biochemical, Effluents, Hematology, Histopathology, Rattus novergicus.
Reference
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